グレンリサーチ株式会社(Corp.): オリゴ DNAおよびオリゴ RNA合成試薬専門の販売会社

<BODY bgcolor="#9999FF"> <table width="100%" border="0" align="center" cellpadding="0" bordercolor="#CCCCCC" class="noborder"> <tr class="noborder"> <td height="50" colspan=3 class="noborder"> <H4 style="margin:2; font-weight: bold; font-color="#000000">グレンリサーチは、DNA・RNA合成試薬製品に特化して販売しております。　弊社では、オリゴDNAやRNAの化学合成や修飾、標識や精製に必要な試薬をホスホアミダイド(アミダイド、特殊塩基、修飾用試薬や標識用試薬)から固相サポート(CPGやポリスチレンなど)まで幅広く取り扱っております。</H4> <table class="noborder"> <tr><td width=33% class=PC ></td> <td width=34% class=PC style="margin:2; font-weight: bold; font-color="#000000"><EM style="margin:5;font-weight : bold; color: 044772;"><u>グレンリサーチ株式会社はオリゴ合成の会社ではありません。　オリゴ合成を業務としている皆様のための会社です。</u></EM></span></td><td width=33% class=PCRight><EM style="margin:5;font-weight : bold; color: 044772;"> <script type="text/javascript"> var d=new Date() var weekday=new Array("(日)","(月)","(火)","(水)","(木)","(金)","(土)") var monthname=new Array("1月","2月","3月","4月","5月","6月","7月","8月","9月","10月","11月","12月") document.write(d.getFullYear() + "年") document.write(monthname[d.getMonth()] + " ") document.write(d.getDate() + "日 ") document.write(weekday[d.getDay()] + " ") </script></td></tr></table> </td> <tr> <td width="34%" height="459" align="center" valign="top"><a href="GlenReports/GR18-16.html"> <p class="blockheader" >高性能精製機High-Efficiency Purification </p> </a> <p class="blockIndent">フローラスタグを施したオリゴ核酸はフローラス固相サポートに対し高い親和性を示します。　この性質は、オリゴ核酸の精製効率を飛躍的に向上させる様々な製品に応用されています。　この高性能な精製技術は、50-100merの長鎖(ロング)オリゴの精製において、通常70-100%の回収率を得る事ができるほど、特に優れた効果を発揮します。　フローラス法を適応させた"CPR II"は、遺伝子解析で使う5'-リン酸化ロングオリゴの簡易精製にも使用できます。</p> <div> <div><img src="GlenReports/Images/GR18-16fig1.gif" width="276" height="195"> </div> <p> </p> <a href="GlenReports/GR18-15.html"><p class="blockheaderLC" >分岐用 dC</p></a> <p align="justify" class="blockIndent">DNA診断法では、diagnostics, the most common approach to the detection of a small amount of target is amplification of the target sequence. However, an alternative approach does exist -direct analysis of the target DNA by signal amplification. This technique requires the synthetic oligonucleotide to contain a primary sequence of interest complementary to the target attached to many identical copies of a secondary sequence to be used for detection. It is the detection of the many copies of the secondary sequence that serves to amplify the signal. The resulting branched oligonucleotide has been aptly described as comb-like, with the primary sequence in the handle and the secondary sequences being the teeth of the comb. The branches in the synthetic oligonucleotide are created using dC-Brancher Phosphoramidite. </td> <td width="34%" align="center" valign="top"> <a href="GlenReports/GR18-13.html"><p class="blockheader" >Sulfurizing Reagent II</p> </a> <p class="blockIndent">A second sulfurizing reagent has been added to our product line to complement our existing Sulfurizing Reagent (Beaucage Reagent). Sulfurizing Reagent II is stable in solution and is offered both in powder form and as a solution for use in popular commercial synthesizers. In addition to good performance in the synthesis of DNA phosphorothioates, Sulfurizing Reagent II demonstrates superior performance in the production of RNA phosphorothioates.</p> <p class="blockIndent"> </p> <p class="blockIndent"> </p> <div align="center"> <img src="Graphics/Structures/p40-4037.gif" width="123" height="50"><a href="GlenReports/GR18-15.html"> </a></div> <p> </p> <p> </p> <a href="GlenReports/GR18-14.html"> <p class="blockheader">Oligonucleotide Caps</p> </a> <p align="center" class="blockIndent">Two new products for the synthesis of oligonucleotides allow the preparation of hybridization probes with increased affinity for complementary sequences. Both are phosphoramidites that can be readily introduced at the 5' terminus via automated DNA synthesis. These oligonucleotide caps favor the formation of stable Watson-Crick duplexes by stacking on the terminal base pair. Melting point increases of over 10 °C per modification can be realized for short duplexes. <p align="center" class="blockIndent">  <a href="GlenReports/GR18-11.html"><p class="blockheader" >AP-dC (G-clamp)</p></a> <p align="center" class="blockIndent">AP-dC (G-clamp) is a very important addition to the modified nucleosides that enhance hybridization since the AP-C....G base pair contains 4 hydrogen bonds, which makes the interaction much stronger than the regular C....G base pair with its 3 hydrogen bonds. The AP-dC modified base is also stable to conditions of oligonucleotide synthesis and deprotection. We envisage applications for G-clamp in the development of short, easily prepared oligonucleotides for use in highly specific single nucleotide polymorphism (SNP) and other in vitro diagnostic assays.</p> <p align="center" class="blockIndent"> </p> </td> <td align="center" valign="top""> <p class="blockheader">RECENT HIGHLIGHTS</p> <h1><font size="-2"><a href="GlenReports/GR17-14.html">Black Hole Quenchers™</a></font></h1> <h1><font size="-2"><a href="GlenReports/GR17-16.html">Internally Quenched Nucleotides</a></font></h1> <h1><font size="-2"><a href="Catalog/supports.html#us2">UNIVERSAL SUPPORT II</a></font></h1> <h1><font size="-2"><a href="GlenReports/GR17-15.html">2'-Fluoro RNA</a></font></h1> <h1><font size="-2"><a href="GlenReports/GR17-13.html">UniCap Phosphoramidite</a></font></h1> <h1><font size="-2"><a href="GlenReports/GR16-21.html">CIS-SYN THYMINE DIMER PHOSPHORAMIDITE</a></font></h1> <h1><font size="-2"><a href="GlenReports/GR16-26.html#desthiobiotin">DESTHIOBIOTIN PHOSPHORAMIDITE & SUPPORT</a></font></h1> <h1><font size="-2"><a href="GlenReports/GR16-22.html"><font size="-4">iso</font>C -<font size="-4"> iso</font>G BASE PAIR</a></font></H1> <h1><font size="-2"><a href="GlenReports/GR16-25.html">TRIMER (CODON) PHOSPHORAMIDITES</a></font></H1> <h1><font size="-2"><a href="GlenReports/GR18-15.html#a101099">Amino-Modifier C6 dG</a></font></H1> <h1><font size="-2"><a href="GlenReports/GR18-15.html#a101511">Potent Inhibition of Cytosine-5-methyltransferases</a></font><BR> <a href="ExtraPages/25GEN5BPAdvance.pdf"> </a></H1> <h1><a href="ExtraPages/25GEN5BPAdvance.pdf"> <p class="blockheader" >Genetic Engineering News Tutorial</p> </a> <p class=PC><font color="#000099">Volume 25, Number 5<br> March 1, 2005</font></p> <p class=PC> A Comparative Study of Universal Supports<a href="ProductFiles/Technical/tech_questions.html"> </a><a href="ExtraPages/highlights.html"> </a><a href="ExtraPages/highlights.html"> </a></p> <a href="ExtraPages/highlights.html"> <p class="blockheader" >August LITERATURE HIGHLIGHTS</p> </a> <p class=PC><strong> Pyrene binary probes for unambiguous detection of mRNA using time-resolved